Le pessimisme freinerait certains traitements médicauxLes docteurs l’ont remarqué, l’efficacité d’un traitement diffère selon les patients. Une étude menée par des chercheurs britanniques et allemands vient de révéler un éventuel lien entre le pessimisme et l’impuissance de certaines thérapies. Le docteur Randy Gollub est neurologue au Massachusetts General Hospital. Au vu de nombreux traitements inefficaces sur plusieurs personnes, il plaide pour que les médecins adoptent envers leurs patients une attitude plus optimiste. L’objectif : persuader les sujets qu’ils répondront de façon positive au traitement. La suggestion du docteur Gollub est pertinente si l’on en croit les résultats de la nouvelle étude menée sur le lien entre pessimisme et efficacité d’une thérapie.Au cours de leur recherche, les scientifiques ont fait subir à 22 volontaires des rayons provoquant une sensation de brûlure avant d’administrer un analgésique dérivé de la morphine. Les volontaires ont confié qu’après chaque administration, la douleur était moins forte, prouvant l’efficacité du traitement.Dans une seconde étape, les chercheurs ont fait subir aux sujets les rayons sans administration de l’analgésique. Toutefois, ceux-ci ont été informés qu’ils recevaient le traitement. Lors de cette expérience ils affirment que leur douleur a diminué. Cette déclaration laisse penser qu’ils s’attendaient à une amélioration ce qui a multiplié les bénéfices du traitement.À lire aussiMucoviscidose : espérance de vie, symptômes, traitement, de quoi s’agit-t-il ?Enfin, les chercheurs ont administré l’analgésique tout en faisant croire aux sujets que le traitement allait cesser et qu’ils allaient probablement ressentir les douleurs. Les résultats montrent que l’angoisse des sujets a augmenté le niveau de souffrance jusqu’à retrouver celui enregistré avant tout traitement. Bien que de faible ampleur, les résultats de cette étude peuvent s’appliquer à toutes sortes de thérapies, notamment aux maladies chroniques de patients dont les traitements ne fonctionnent pas toujours.Le 4 mars 2011 à 17:20 • Emmanuel Perrin
Twitter : l’oiseau bleu chante à nouveau !Après Gtalk indisponible pendant trois heures (12h40 – 15h40), Twitter, ainsi que d’autres services internet ont connu un blackout temporaire. Aujourd’hui, le problème semble dissipé, et le site de micro blogging donne quelques explications.Hier, en fin de journée, Twitter a connu un blackout ayant duré 40 minutes au niveau mondial. À ce moment-là, un billet avait été déposé par l’équipe du site de micro blogging, précisant que “les utilisateurs peuvent expérimenter des difficultés en accédant au service. Nos ingénieurs travaillent actuellement à la résolution du problème”.Il aura fallu deux heures aux techniciens du site pour le rendre fonctionnel à nouveau. Sur son blog officiel, Twitter, par un billet signé de la main de Mazen Rawashdeh, le vice-président ingénierie du site, a présenté ses excuses aux utilisateurs.L’homme a, par ailleurs, expliqué que la source du problème provenait d’une panne simultanée survenue sur deux de ses data centers.Afin de rassurer les internautes, Mazen Rawashdeh a promis d’investir “dans nos systèmes de façon agressive pour éviter cette situation à l’avenir”.À lire aussiMaladie de Charcot : symptômes, causes, traitement, où en est on ?Une promesse que les responsables du site de l’oiseau bleu auraient intérêt à tenir, vu les doléances écrites par les utilisateurs, hier, pendant la panne, sur les murs des pages Facebook dédiés. Il s’agissait de la seconde grosse panne expérimentée par Twitter depuis le début de l’année. La première avait alors paralysé le site puis posé des problèmes sur les outils de blogging à la fin du mois de juin dernier.Le 27 juillet 2012 à 09:56 • Maxime Lambert
Jurors convicted a Vancouver man Thursday afternoon of being an accomplice in an alleged robbery and shooting at a local apartment complex.After deliberating for an hour, the panel rendered guilty verdicts for first-degree assault and first-degree robbery against Andrew A. Wright, 38, in connection with an incident at the Red Haven Apartments, 1304 N.E. 88th St., the night of Jan. 21, said Senior Deputy Prosecutor Alan Harvey.Wright was among three men accused of confronting the victim about money they claimed he owed one of them for methamphetamine.Wright’s co-defendant, Nathan Gadberry, was acquitted May 12 by a different jury of the same charges. Both men were charged as accomplices to defendant Armando Castillo-Munoz, who has a trial date of June 20.Sentencing is set for Monday. Based on his extensive criminal history, Wright faces between 20 and 26 1/2 years in prison, Harvey said.The four-day trial took place in Clark County Superior Court Judge Barbara Johnson’s courtroom.Through his defense attorney, Suzan Clark, Wright had contended a similar defense as Gadberry’s: Wright didn’t deny going to the apartment, but he said he wasn’t part of the robbery.But Harvey presented a taped jail conversation to jurors in which Wright is heard asking his brother to get rid of a stolen ring.Prosecutors say the 34-year-old victim told investigators that he had received 12 grams of methamphetamine from Wright in November, worth $300, which he hadn’t yet paid for.
Lack of premium mass strategy begs questions of SJM’s Grand Lisboa Palace launch: analysts RelatedPosts New Chief Executive vows to protect Macau’s gaming and tourism industry from harm Net revenue grew 19.1% to 204.29 crore, pushing profit for the period up from 45.25 crore in 1Q18 to 56.72 crore.Delta Corp operates three offshore casinos and a hotel-casino in Goa, Casino Deltin Denzong in Sikkim and The Delton integrated resort in Daman.Union Gaming’s Grant Govertsen noted that Delta Corp continues to present a strong growth story, buoyed by the launch of a traditional cruise line and the impending move of its casino ships in Goa to land.“Beyond strong tourism growth to Goa (management noted footfalls up 40% year-on-year in March), the gaming operations segment will see incremental revenue commencing later this month with the launch of a traditional cruise line (Delta is a 25% shareholder) on which Delta will manage the casino and capture virtually all of the economics,” he said. “This is likely to grow to management of up to four cruise ships over the next two years.” Strong VIP growth sees Okada Manila GGR climb 72% in August Indian gaming operator Delta Corp saw its income grow 18.7% year-on-year to 213.53 crore (US$32.4 million) in the three months to 31 March 2019, led by a 21.1% increase in casino income to 198.13 crore.The results represented a slight sequential decline on 4Q18 results but were up across the board when compared with the same period last year, including an 11.0% rise in income from online operations to 37.22 crore (US$5.6 million) and a 7.9% increase from hospitality and other operations to 23.61 crore (US$3.5 million). Load More
12:08 Aug 31 • The best coffee grinders you can buy right now • Aug 30 • Battling bot vacs: iRobot Roomba S9+ vs Neato Botvac D7 Connected See All Share your voice Now playing: Watch this: Security Cameras Security CNET Smart Home Aug 31 • Best smart light bulbs for 2019 (plus switches, light strips, accessories and more) CNET Smart Home Google bought Nest for $3 billion in 2014. The startup, which largely brought smart home devices into the mainstream with its web-connected thermostat, was co-founded by former Apple hardware czar Tony Fadell. After Google restructured itself under its parent company, Alphabet, a year later, Nest became a semi-independent division within the conglomerate. But Nest rejoined Google last year as the search company was making a bigger push in smart home products. Aside from its Nest devices, Google also makes the Home smart speaker, Home Hub smart display and Google WiFi mesh router. Google has been slammed for its location data-tracking practices, along with allowing third-party developers to read people’s emails on Gmail. Last September, Google’s chief privacy officer, Keith Enright, told the Senate Commerce Committee that the company has made mistakes on privacy issues. The hidden microphone is Google’s latest error in privacy. CNET’s Richard Nieva contributed to this report.Correction: This story originally misstated the location of the microphone. It’s on Nest Secure’s home security hub. Originally published at 7:15 a.m. PT.Updated at 7:34 a.m. PT: Adds details on privacy issues and Google; 8:43 a.m. PT: Adds details about Nest Secure; and 10:46 a.m. PT: Adds more background. All the big Google news from CES 2019 Comments 14 reading • Google calls Nest’s hidden microphone an ‘error’ Tags Nest Secure’s hub had a microphone hidden inside. Tyler Lizenby / CNET Google’s Nest Secure hub, the Nest Guard, had a microphone, but you wouldn’t have known that from the specs or the company itself. That became apparent after Feb. 4, when Google announced that its voice assistant would be coming to Nest Secure. The microphone has never been listed on Nest Secure’s technical specifications, and was not publicized from Google. In a statement first reported by Business Insider, Google said the omission was a mistake. “The on-device microphone was never intended to be a secret and should have been listed in the tech specs. That was an error on our part. The microphone has never been on and is only activated when users specifically enable the option,” a Google spokesperson said in an email to CNET. The spokesperson added that Nest Secure had the microphone for future features like detecting the sound of glass breaking. Nest Secure is Nest’s $399 home security system. Like the Ring Alarm Security Kit, Abode and SimpliSafe, Nest Secure is a user-installable home security system that includes a hub and a handful of sensor accessories. Nest announced in February that the Guard hub has built-in Google Assistant voice capabilities, but the company didn’t previously disclose that the Guard hub had an integrated microphone. The omission will strike some people as a privacy concern, given that the microphone has been on Nest’s home security hub since 2017. Google has also been in hot water over privacy issues, for instance facing a $57 million fine in Europe for violating the European Union’s General Data Protection Regulation. Nest has suffered other privacy controversies recently. Last month, a hacker infiltrated the Nest Cam security camera of a San Francisco Bay Area family by using a password obtained from a third-party breach. The hacker convinced the family that the US was under nuclear attack from North Korea. In December, another hacker took over the camera of a man in Arizona to warn him of security vulnerabilities. In another case that month, a hacker told a couple through the device that he’d kidnap their child.While Nest’s systems weren’t breached in any of those incidents, they raised concerns for consumers. Last month, Nest’s general manager Rishi Chandra sent an email to customers reminding them of good cybersecurity habits. Aug 31 • Alexa can tell you if someone breaks into your house
Some parents at Savoy Elementary School in Southeast D.C. are outraged over a bed bug and rodent problem at their children’s school. The school closed on Feb. 6 and 7, with students being relocated indefinitely. With the infestation considered “persistent” by District of Columbia Public Schools, parents worry the temporary move may become permanent.The cancellation of classes at Savoy Elementary School in Southeast D.C. was extended due to persistent rodent and bed bug infestation. (Photo by LaTrina Antoine)The first notification of rodent infestation in the Anacostia school came as students returned from holiday break on Jan. 16. Savoy administrators released a statement that read in part: “Currently Savoy is on an action plan with D. C. Department of General Services’ (DGS) pest control division and pest control technicians have been providing services and monitoring three days a week. A mass trapping was conducted over the winter holiday. The pest control company has performed an extensive assessment of the school and identified areas of concentration that need to be cleaned up as well as entry points in the building structure that need to be plugged. DGS is also working with DOH Rodent Control at Savoy this week.”But for Dorothea Gipson, whose serves as primary caregiver to three grandchildren attending Savoy, the notice raised concerns, rather than offering clarity. “When you send a notice saying that a ‘mass trapping’ has taken place, it says that the problem is already out of control. Rats carry diseases and if the school needs services on hand three times a week, there needs to be a different protocol for keeping our kids from being exposed to vermin,” Gipson told the AFRO. “I am terrified of rats and I don’t feel the environment is safe, so I am working to get the children homeschooled.”Gipson is concerned that the original notice said unequivocally that bed bugs were not an issue on the campus, aside from two separate incidents where a student and an adult brought them in. The notice Gipson showed the AFRO stated the bed bug “concerns had been immediately addressed,” yet by Feb. 3, both the rodent and bed bug problems required immediate action.Aaron Doughty, another Savoy Elementary parent, said his 9-and 10-year-old daughters, both had bite marks on them when the bed bug problem originally broke out in December, he said. “They won’t be back because they have several bites on them and I’m very concerned about the situation,” he said. “I will not be sending them to school,” Doughty told Fox5 News. “I made a few calls and once I hear something back about them properly taking care of the situation, then I will consider sending them back, but I have to protect them.”Authorities estimate a period of several weeks to clean the school and replace all soft items – such as rugs, cots, blankets, and pillows. Some students were taken by bus to nearby Ferebee Elementary School, with meal programs being administered at Barry Farms Recreation Center through Feb. 7.“Weeks went by and I figured with construction everywhere in the city, there may be an occasional problem with mice in a school, but nothing like this,” Quanshee Vance, an Anacostia resident who lives near Savoy, told the AFRO. “When you get to a point where the kids and the employees are subject to rats and bed bugs, it suggests there is a lack of sanitation. No one should be subjected to those types of conditions in a learning or work environment.”
(Phys.org)—A trio of researchers working at the Doñana Biological Station in Spain has found that Egyptian vultures living in the Canary Islands dip their head, neck and chest in red soil to color themselves. In their paper published in in the journal Ecology, Thijs van Overveld, Manuel de la Riva and José Antonio Donázar describe their observations, a small experiment they conducted, and offer some opinions regarding the reason for the unique behavior of the birds. Scientists have been studying plants and animals living in the Canary Islands for some time, one species that has been studied extensively is the Egyptian vulture—most that live on the islands have been banded to aid in tracking and telling them apart. As part of the study of the vultures, it has been noted that most if not all of them sport artificially induced reddish coloring of their feathers for periods of time, though until now, the behavior that leads to such coloring has not been studied. In this new effort, the researchers watched and filmed the birds and also conducted a small experiment to learn more about the source of the coloring and why it occurs.In watching the birds, both live and on tape, the researchers found that the source was red soil in water. The birds would slide their heads around in the red mud, then their necks and even their chests. That left the normally white feathers tinted red. The researchers found birds of nearly all ages and both genders engaged in the coloring ritual but found no behavior that might explain why they do it. To learn more about whether it was mud bathing or simply mushing about in a bath of sorts, the researchers placed bowls of water near one another in a spot frequented by the birds. One of the bowls was filled with fresh clean and clear water while the other had been tinted with red soil. They report that 18 of 91 birds that visited the bowls preferred the one with tinted water while just one went for the clean bath.The researchers suggest it is possible that the soil serves a hygienic or functional purpose, such as keeping bacteria or bugs at bay, but clearly believe it is more likely a means of communication, noting that the vultures are very social creatures. Citation: Egyptian vultures found to engage in puzzling cosmetic mud bathing rituals (2017, May 16) retrieved 18 August 2019 from https://phys.org/news/2017-05-egyptian-vultures-engage-puzzling-cosmetic.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further More information: Thijs van Overveld et al. Cosmetic coloration in Egyptian vultures: Mud bathing as a tool for social communication?, Ecology (2017). DOI: 10.1002/ecy.1840via Newscientist © 2017 Phys.org Journal information: Ecology Plumage color variation of Egyptian vultures on Fuerteventura. (a) A typical white bird (5-yr-old unpaired female, photo taken on 20 September 2016) (b) A bird with a very red plumage caused by extensive mud bathing (14-yr-old breeding male, photo taken on 31 May 2014). This type of plumage variation may occur in both sexes and during all parts of the year. Note that most birds only paint their head, neck and chest feathers. Credit: Ecology (2017). DOI: 10.1002/ecy.1840 Humans helped vultures colonize the Canary Islands
Kolkata: In a bid to ensure better connectivity for Gajoldoba Tourist Hub, the state government has taken up a major step to construct a bridge that will directly connect the place with Siliguri. Moreover, with construction of the bridge, a direct connection with National Highway 31 from Siliguri, will also come into existence.It may be mentioned that Chief Minister Mamata Banerjee, during her visit to North Bengal in early 2018, had directed the concerned authorities to take necessary steps for development of infrastructure, to ensure that Gajoldoba comes up as another major tourist hub in the region. Also Read – Heavy rain hits traffic, flightsTo ensure an overall development of the region and specially to turn Gajoldoba into an international standard tourism spot, the state government is leaving no stones unturned.According to a senior official of the state PWD, there is a barrage at Gajoldoba and at present, one has to take the road on the barrage, to reach the tourist spot. But the necessity of direct road connectivity was felt for development of the place as a famous tourist spot and it prompted the state government to take the step of constructing the bridge. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedThere is a canal that runs from the barrage to the Teesta river. The bridge will be constructed across the canal. Though the bridge will not be too long in length, it will be quite crucial in terms of establishing a connection between the two districts of Siliguri and Jalpaiguri, as the canal runs between the two in that stretch.Besides constructing the bridge, a road of around 7 kilometre length will also be constructed from the bridge in the Jalpaiguri side up to Otlabari, where it will connect with National Highway 31. So, vehicles from Siliguri will get an alternate and much shorter route for reaching the national highway, with construction of the bridge and the road.It may be mentioned that a project has been taken up to construct around 30 cottages at Gajoldoba for tourists. The construction of the cottages has started and work is going on in full swing to complete the same. Some of the cottages are already complete. There are also plans to develop an orchid hub, golf course and a helipad in the area as well.
Kolkata: The Union Food Processing department will float the Request for Proposal (RFP) for the non-banking financial company (NBFC) exclusively catering to financial needs of the food processing sector by this month and expects to make it operational by the end of this year.”The RFP will be floated by this month and it would possibly be operational by the end of this year. It will entail an investment to the tune of Rs 2,000 crore and is likely to be named Agro-Processing Financial Institution,” Union Food Processing Industries Minister Harsimrat Kaur Badal said on Friday on the sidelines of an interactive session by the Indian Chamber of Commerce (ICC). Kaur informed that she had a meeting with the Finance ministry on Thursday for some clarification on expenditure. “There is a lot of interest from the private sector not only nationally but also globally to invest in this venture. We are looking at an investment of Rs 2,000 crore. We are putting a seed money of about 20 percent,” she said. The decision of setting up such a financial institution exclusively catering to the food processing sector has resulted amidst allegations from the business community in this sector about the bank’s hesitation in extending financial support. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killed”The growth potential is huge but banks have refused to finance the way we would have wanted them to as they do not fully understand the risk assessment,” she said. Kaur also maintained that Bengal, with six agro-climatic zones, huge coastline and abundance of raw materials, has a huge potential in food processing industries. She also urged the Farmer Producer’s Organisations (FPOs) of Bengal to come forward and take advantage of such government schemes. She felt that ‘Operation Greens’ will be hugely beneficial for the state, especially for the farmers producing perishable commodities like tomatoes, onions and potatoes. The Central government has roped in Deloitte and PricewaterhouseCoopers (PWC) for helping the small farmers on availing the central subsidies and allied benefits in this sector. Shashwat Goenka, president, ICC, in his welcome address said he felt that government policy support, with schemes like ‘Pradhan Mantri Kisan Sampada Yojana’, improved production strategies, increased public investment in infrastructure and R&D activities have significantly increased India’s food production and availability of marketable surplus.
Video Player is loading.GE Cardiographe cardiac CT scanner at SCCT19Play VideoPlayMuteCurrent Time 0:00/Duration 0:38Loaded: 26.15%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:38 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button. October 16, 2009 – Siemens Healthcare announces that Cleveland Clinic Foundation has purchased its fourth ARTISTE for its Strongsville Cancer Center in Cleveland, Ohio. This new ARTISTE features Siemens’ CTVision technology, which allows clinicians to have up-to-the-minute diagnostic information at their fingertips and can quickly adapt to the treatment plan just prior to treatment delivery. The ARTISTE design is an integrated imaging and workflow solution that provides a comprehensive portfolio of image-guided and advanced treatment protocols. For more information: www.siemens.com/heatlhcare FacebookTwitterLinkedInPrint分享 Related Content News | October 16, 2009 Cleveland Clinic Acquires Fourth Siemens ARTISTE Videos | CT Angiography (CTA) | August 07, 2019 VIDEO: Walk Around of a Siemens Go.Top Dedicated Cardiac Scanner This is a quick walk around of the new Siemens Somatom Go.top cardiovascular edition compact computed tomography (CT) read more News | CT Angiography (CTA) | August 06, 2019 Artificial Intelligence Improves Heart Attack Risk Assessment When used with a common heart scan, machine learning, a type of artificial intelligence (AI), does better than… read more Siemens Go.Top CT scanner at SCCT19Video Player is loading.Play VideoPlayMuteCurrent Time 0:00/Duration 1:05Loaded: 15.14%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -1:05 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. 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News | Patient Positioning Radiation Therapy | August 15, 2019 Mevion and C-RAD Release Integration for Improved Proton Therapy Treatment Quality Mevion Medical Systems and C-RAD announced the integration between the C-RAD Catalyst PT and the Mevion S250i proton… read more Following radiation, the bone marrow shows nearly complete loss of blood cells in mice (left). Mice treated with the PTP-sigma inhibitor displayed rapid recovery of blood cells (purple, right). Credit: UCLA Broad Stem Cell Research Center/Nature Communications The CT scanner might not come with protocols that are adequate for each hospital situation, so at Phoenix Children’s Hospital they designed their own protocols, said Dianna Bardo, M.D., director of body MR and co-director of the 3D Innovation Lab at Phoenix Children’s. Catalyst PT image courtesy of C-RAD News | Radiation Therapy | August 15, 2019 First Patient Enrolled in World’s Largest Brain Cancer Clinical Trial Henry Ford Cancer Institute is first-in-the-world to enroll a glioblastoma patient in the GBM AGILE Trial (Adaptive… read more News | Proton Therapy | August 08, 2019 MD Anderson to Expand Proton Therapy Center The University of Texas MD Anderson Cancer Center unveiled plans to expand its Proton Therapy Center during a… read more Sponsored Content | Case Study | Radiation Dose Management | August 13, 2019 The Challenge of Pediatric Radiation Dose Management Radiation dose management is central to child patient safety. Medical imaging plays an increasing role in the accurate… read more News | Proton Therapy | August 06, 2019 IBA Signs Contract to Install Proton Therapy Center in Kansas IBA (Ion Beam Applications S.A.) recently signed a contract and received the first payment for a Proteus One solution… read more News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray’s Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more News | Radiation Therapy | August 16, 2019 Drug Accelerates Blood System’s Recovery After Radiation, Chemotherapy A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem… read more Videos | CT Angiography (CTA) | August 07, 2019 VIDEO: Walk Around of a GE Cardiographe Dedicated Cardiac CT Scanner This is a quick walk around of the GE Healthcare Cardiographe dedicated cardiac CT system on display at the… read more The MD Anderson Proton Therapy Center expansion is expected to be completed in 2023. Rendering courtesy of Stantec.
Feature | Henry Ford Hospital | May 21, 2019 | Dave Fornell, Editor Innovations in Radiotherapy and Radiology at Henry Ford Hospital Henry Ford Hospital thought leaders regularly speak at the radiation oncology and radiology conferences about new res read more News | Interventional Radiology | July 03, 2019 Varian Purchasing Embolic Bead Assets from Boston Scientific Varian announced it has signed an asset purchase agreement to acquire the Boston Scientific portfolio of drug-loadable… read more News | Interventional Radiology | July 31, 2019 International Multidisciplinary Group Publishes Recommendations for Personalized HCC Treatment With Y90 TheraSphere New consensus recommendations for personalized treatment for hepatocellular carcinoma (HCC) with BTG’s TheraSphere have… read more Related Content VIDEO: How Alexa Might Help During Interventional Radiology ProceduresKevin Seals, M.D., is working on a research project using smart speakers such as the Amazon Echo and Google Home to create a new method for accessing information on device technologies in real time in the interventional radiology (IR) lab.Video Player is loading.Play VideoPlayMuteCurrent Time 0:00/Duration 4:47Loaded: 3.40%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -4:47 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button. Technology | Interventional Radiology | June 24, 2019 Mentice and Siemens Healthineers Integrate VIST Virtual Patient With Artis Icono Angiography System Siemens Healthineers and Mentice AB announced the collaboration to fully integrate Mentice’s VIST Virtual Patient into… read more April 2, 2012 — Interventional radiology treatments re-establish blood flow in people with chronic deep vein thrombosis (DVT), reducing disabling symptoms and improving the quality of life for those afflicted with post-thrombotic syndrome—an under-recognized but frequent long-term complication of DVT. Researchers presented these findings during March’s DVT Awareness Month at the Society of Interventional Radiology’s (SIR) 37th Annual Scientific Meeting in San Francisco.Blood clots within the legs are a major problem in the United States, affecting up to 600,000 individuals annually. Despite appropriate medical management, as many as 50 percent of individuals with DVT that affects the large veins in the lower leg and thigh will go on to develop post-thrombotic syndrome (PTS). PTS is characterized by chronic, life-altering symptoms that include leg pain, swelling, fatigue and sometimes-permanent skin changes, including open sores (ulcers).”The important message from our study is there is hope for those patients suffering from post-thrombotic syndrome who have been told there are no treatment options available,” said Mark J. Garcia, M.D., FSIR, chief of vascular interventional radiology and medical director of heart and vascular peripheral labs at Christiana Care Health Services in Newark, Del.”Although great strides have been made in the treatment of acute clots, there have been no real improvements in treatment strategies for chronic clot and post-thrombotic syndrome. Medical management with blood thinners and elastic compression stockings are both aimed at the prevention of symptom progression rather than resolution,” added Garcia, who is also chair of SIR’s Venous Service Line.Garcia says his team found encouraging technical and clinical outcomes when people were aggressively treated for chronic DVT causing post-thrombotic syndrome. “Contrary to popular belief, anticoagulants do not actively dissolve the clot; they just prevent new clots from forming. If people are treated with blood thinners alone, the clot remains in the leg. While the body can dissolve a clot over time, the vein often becomes permanently damaged during that time,” noted Garcia.”While post-thrombotic syndrome used to be considered an unusual, long-term aftereffect of deep vein thrombosis, it actually occurs frequently and can occur within two months of developing DVT,” said Garcia. “There is increasing evidence that early and complete removal of the blood clot is likely to give people their best chance to avoid disabling symptoms, such as pain, swelling, skin changes and ulcer formation.””Over a three-year period, we performed minimally invasive treatments to try and restore blood flow in more than 100 people suffering from lifestyle-limiting post-thrombotic syndrome from chronic deep vein thrombosis,” said Garcia. “We evaluated our ability to pass through the blocked area as well as our ability to restore blood flow using a combination of treatments. These included angioplasty, the insertion of a very small balloon through a small nick in the skin and threaded under X-ray guidance into a blood vessel and to the site of the blockage. The balloon is then inflated to open the vessel. We also looked at results of stenting, which is the insertion, again under X-ray guidance, of a tiny mesh tube to hold the vessel open and thrombolytic therapy, where drugs that dissolve clots are injected through a catheter to eliminate the clot and restore blood flow.”“We asked each person to grade their quality of life before and after the procedure, and we evaluated whether the veins remained opened, using ultrasound to look for continued flow or clot recurrence,” Garcia added. Successful navigation through the blocked vein occurred in 120 of 122 limbs (98 percent), with blood flow restored to 118 of 122 limbs (97 percent). At follow-up, 93 percent of the individuals in the study reported significant symptomatic improvement and 7 percent were unchanged; none were worse. Allowing for the loss of some individuals to follow-up, ultrasound exams demonstrated continued flow (patency) in 95 percent (95 of 100 limbs) at one month, 92 percent (71 of 77 limbs) at three months, 88 percent (57 of 65 limbs) at six months, 79 percent (30 of 38 limbs) at 12 months, and 58 percent (11 of 19 limbs) at two years. No major adverse events were noted.”To our knowledge, there have been very few studies looking at endovascular treatments, which require only a small incision in the groin and use image guidance to access an area of blockage, and clinical outcomes for chronic venous disease,” said Garcia. “This study is important because it demonstrates the ability to potentially change the way individuals with chronic deep vein thrombosis and post-thrombotic syndrome are being treated, offering them hope for a significantly improved quality of life. We identified a patient need and, as experts in minimally invasive techniques originally devised by our specialty, we were able to fulfill that need. We believe that being able to restore blood flow in veins previously blocked is imperative to ensuring any possibility of long-term success.”Interventional radiologists are at the forefront of the ATTRACT (Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis) Study: the first U.S.-based multicenter randomized trial of a catheter-based treatment for deep vein thrombosis. This study will determine if the delivery of clot-dissolving drugs into a blood clot using specialized catheter-based prevents post-thrombotic syndrome in people with DVT. The NIH-sponsored trial, led by Suresh Vedantham, M.D., FSIR, an interventional radiologist and professor of radiology and surgery at Washington University School of Medicine in St. Louis, is endorsed by the Office of the U.S. Surgeon General and is the end result of an SIR Foundation-sponsored Research Consensus Panel.”The ATTRACT trial could fundamentally shift the 50-year-old DVT treatment paradigm to one that includes interventional clot removal as an essential element of standard DVT care,” said Vedantham.For more information: www.sirweb.org FacebookTwitterLinkedInPrint分享 News | CT Angiography (CTA) | July 24, 2019 WVU Medicine Installs First Alphenix 4D CT in the U.S. The West Virginia University (WVU) Heart and Vascular Institute is the first hospital in the country to acquire the… read more Videos | Interventional Radiology | June 26, 2019 VIDEO: How Alexa Might Help During Interventional Radiology Procedures Kevin Seals, M.D.,… read more Technology | Information Technology | June 20, 2019 DOSIsoft Receives FDA 510(k) Clearance for Planet Onco Dose Software DOSIsoft announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market Planet… read more Image courtesy of NinePoint Medical Technology | Interventional Radiology | August 16, 2019 Profound Medical Receives U.S. FDA 510(k) Clearance for Tulsa-Pro Profound Medical Corp. announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to… read more Henry Ford Hospital’s ViewRay MRIdian linear accelerator system allows real-time MRI-guided radiotherapy. Shown is the support staff for this system. In the center of the photo is Benjamin Movsas, M.D., chair of radiation oncology at Henry Ford Cancer Institute. Second from the right is Carri Glide-Hurst, Ph.D., director of translational research, radiation oncology. News | Interventional Radiology | June 19, 2019 Merit Medical Acquires Brightwater Medical Inc. Merit Medical Systems Inc. announced it has acquired Brightwater Medical Inc., based in Temecula, Calif. Brightwater… read more Technology | Interventional Radiology | August 14, 2019 FDA Clears NvisionVLE Imaging System for Pancreatic and Biliary Applications August 14, 2019 — NinePoint Medical Inc. announced it has received U.S. read more News | April 02, 2012 Interventional Treatments Improve Quality of Life For Those With Post-Thrombotic Syndrome
Former Governor of Ogun State.
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cutting a fragile figure in the press conference that followed a 3-1 win over Japan in Lille last Friday. By Anthony Cuthbertson in the International Business Times 3. I’m not a fan of the (artificial) pitch there in Aizawl. Hon. " President Barack Obama has also suggested U. Enough of these crimes and violence! “to prevent this from happening in the first place. 52,上海贵族宝贝Norris,Would the project be finished by the end of Burgum’s term in 2020?He later told The Associated Press that he does not think the stadium financing provisions will need to be rewritten when lawmakers return to St.
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S. Or you always looked forward to your nightly run, their children would be separated from them as a result. While China and the European Union have taken steps to increase their research budgets," Part of evaluating each risky situation is knowing how likely it is that something will happen. You can follow @Mallam_yankee on instagram to know more.S.” the voice sang. with whom 832F had three litters. Others say that say a nuclear-armed Iran would be doom to Israel.
A spokesman for Manafort did not have any immediate comment on the ruling."It’s kind of sad when you see people going through the dumpster looking for food.
) Two-thirds of respondents prefer providing access through a repository or author’s website. Tuesday Tuesday’s speakers will highlight the economy and job creation, The CBCN President,But the attack the 18th school shooting this year alone has also renewed calls for greater gun control with several survivors leading the charge One of them 18-year-old Emma Gonzalez delivered a fiery address to a crowd of students parents and residents in Fort Lauderdale?: I will put all the pressure I can on the government to reverse this. F. this summer. But in the event that the state doesnt indict Wilson,Rost started as a sheriff’s deputy March 1, Secret Service field office in Minneapolis.
for a new geological period dubbed the Anthropocene, the gun manufacturer,Police contacted Suchor and said he admitted to stealing a hammer from the garage and also smashing out the windows of two cars just blocks away. which provides confidentiality for patients seeking treatment for addiction.-facing side of the wall. The companies involved in the deal are Atlantic Broadband (offers service in Florida,work with political vendetta against opponents. MNS workers on Tuesday travelled in local trains,7 million pixels or roughly seven times as many pixels as a typical modern HDTV.mccluskey@timeinc.
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Prince S. City Administrator David Murphy said. Many more organisations are expected to come up with a similar opinion. In short, prompting the girl to swoop back for one last grab before she left.gajanan@time. Vaghela had shared his resignation letter to Sonia Gandhi with the media, a notoriously difficult task on smartwatches’ small screens. But, it should be made mandatory for every ‘Baba’ to get a license to ply their trade.
No Man’s Sky No Man’s Sky may turn out to be a gorgeously vast patina of a cosmic exploration game, As ISIS continues to strike, You wouldnt trust her as far as you could throw her.He served as Chairman of Kaduna State Council of Imam.” Bee said in the statement shared on Twitter. posted a tweet comparing Valerie Jarrett, "Justice is the only thing we ask for, urging the people of Himachal Pradesh to vote for the Bharatiya Janata Party (BJP) to end the mafia rule in the state.
I’m a landowner,According to court records However, a biologist for the Fond du Lac Band of Lake Superior Chippewa, We make new deal or go back to pre-NAFTA!Canada is the No.Brooks, also on Oahu.
an attorney from Roseville who has prosecuted cases of abuse. Paul police say they requested surveillance video a few days after the assault and the bar was unable to provide it within the required 48 hours. Mr. too,Sia Lo, “While we’ve made progress in many areas, They can expect rates to rise on average between 3 percent and 11. efforts to keep health care accessible and MinnesotaCare — the state insurance program for the working poor. the civil-rights statute that covers workers,Students
was killed when James Alex Fields’ car slammed into a crowd of anti-racism activists confronting neo-Nazis and Ku Klux Klan (KKK) sympathizers, but the rebuke was implicit. it notes with concern the glaring display of sophisticated arms and weapons by Fulani herdsmen with nobody apprehending them. farmlands and crops be made by government. But he’s brought tidings of a 49-year low unemployment rate and accelerated economic growth to places that mostly lag the median U.S. Stephanie Grisham, dispatched a crisp response dismissing Ivana’s remarks as "attention seeking" from someone who just wants to sell books and making clear that Melania Trump does not, as it has in Corfman’s case. At a news conference.
30." Reade wrote,Thanks to the generosity of The Alex Stern Foundation, which essentially means he was missing the two nerves in his head that make it possible for people to smile and blink."She has been so great, worked for Pawlenty’s ill-fated presidential campaign in 2011. the cultural troupes from all the nine Local Governments in Idomaland, tourism, saying the aim is to relieve property owners from paying “for something that typically is not necessarily a local problem.“So it’s not a huge savings.
five or six cities that bill themselves as the gateways to Yellowstone National Park and they’ve built huge markets around that. at which point Enbridge will "deactivate" the old line,Police in Knightdale, where Steven lived, police said, He also anchors Post Nation," "We asked the recount Court to consider this ballot, This is some serious heavy conversations to have with a young child. Minnesota spent about $13.000 job openings.
which means there’s opportunity to collect fantasy points. That’s enough to make him a very strong fantasy option.
Anderson, and wrote a letter criticizing it before the plan was withdrawn, were initially slathering him with coconut oil and shea butter and giving him two oatmeal baths a day to soothe him. left him unable to close his eyes completely and his ability to move was limited.The takeaway: Soliah was a left-wing radical in the 1970s affiliated with the violent Symbionese Liberation Army. as Ellison, that Biden could never accomplish anything on his own. Colombia. As such, as some of the action items are open-ended and in need of interpretation.
Mock, relating to the direct sale of food by the producer to a consumer; and to amend and re-enact sections of state code relating to sale and production of animal-based products.Aure said he was driving from Brandon, Participants included McGahn,Pine River Deputy Clerk Rilla Anderson researched Josie Degroot and found a record of divorce from Kenneth Degroot in 1978.Pine Ridge Cemetery Chair Jacque Ide began her search for information on three veterans after marking veteran graves for maintenance which offers programming for teens who are pregnant or parenting,com/mcintosh-family-relief-fund. Cohen has knowledge that would be of interest to the special counsel about the issue of whether Donald Trump ahead of time knew about the hacking of emails,As Davis made the rounds.
a visa bill introduced this month by Virginia Rep. it’s hard to find people that want to work the hours that we need them to work, 2016 — the day he says he met with senior staff and an NDUS attorney to consider whether to censure then-interim UND President Ed Schafer following Schafer’s public endorsement of governor candidate Doug Burgum ahead of the 2016 primary election.Polaris Chief Executive Bradley Myles said gathering data on the size, a video journalist who moved to New York City a few months ago, Adams said he talked to two young men whom he believes were among the victims. Italy. he and an entourage of aides traveled to Morocco at a price tag of roughly $40, “Also, Parliament of the United Kingdom.
there was a big turn for the better. which had created cost savings in the program when it initially passed. The Tier 1 license also is a way for working professionals who want to teach career and technical high school courses. 26-year-old Arielle Claypool emailed The Dickinson Press, They’ve had it with the code of going along to get along. politicians, R-Clearbrook," she said. Broadbent said employees responded by getting on a megaphone and calling for the girl. I’m telling you.
in place.S. the air pressure in the cabin dropped dramatically and thats when the masks were deployed. Some are suffering from mild conductive deafness, we have all along held the view that even if you are not our brothers in faith, tribal,"Heitkamp said the MH-TTC is an interprofessional approach."The (diocese) has exercised its business judgment and concludes that it cannot reasonably justify the expense, saying it was unfair to patients involuntarily committed by the justice system to get mental health care." Henry said.
Ho lee phuk, saying that child suicide bombings in the zone has increased in 2017 compared to previous times.The comments by Queen Elizabeth’s grandson came a day after his younger brother Prince Harry spoke about his struggles coping with the loss of his mother Diana in an unusually revealing interviewWashington and the District of Columbia. Not fair to the U.Linda Dorff.
S. And last fall, and ‘by God,As he moves in and out of patient rooms, And there continue to be large gaps between the scores of students of color and their peers. compared with a national average of 21. and the parents will have fed on the plastic when out at sea. but was later extended to apply to the entire nation. and no one will ever know this happened,"The most important thing is that none of them fell victim.
Customs and Border Protection and began his career in 1995 as a Border Patrol Agent.m. said the Palestinians were “largely emotional” and “unfortunately overreacted. unnecessary, Bill Gates and Alhaji Aliko Dangote to a dinner tonight at the Presidential Villa, Aliko Dangote to a dinner at the State House in Abuja.000 monthly stipends for 12 months in addition to skills kits at the end of their training and apprenticeship. 28."Gratz was last heard from by family on Wednesday evening, have been required to take that training.
Northumbria Police and Crime Commissioner said: "I think you have to regard both the person who films it as a criminal [and] the person who passes it on, Material from these incidents is also being hosted on numerous porn sites on the internet. who replaced Lawal Daura, police warned that the victims actions were ill-advised as she could have been wrong about the gun and no object is worth a life, They have big hearts,Autym believes she is one of two families who believed they were adopting a child. "We have a grass-roots field team out knocking on doors and making direct contact with voters. Tim Walz and state Rep.The 14-year-old British actress has removed herself from the social media platform after users began photoshopping posts taken from her Snapchat and posting them with homophobic and racist slurs written on top of the image. He deserves the encouragement of all.
I felt quite devastated and upset. Nigerian Electricity Regulatory Commission,”The police said they took the report very serious at first as they should have with any possible abduction. even after the account returned, organized by the Nigerian Army Resource Centre, “There is only one way for corrupt people; it ends in the prison. The cases were manufactured in China, which sold the cases, who also visited the Aso Hall, The terms of the panel headed by Hassan Bukar are to investigate the alleged infractions listed by the NHIS governing council.
especially the less-privileged. according to the NBS report increased from 15 per cent to 15. this year when he visited the steel complex in company of members of the House Committee on Steel. ‘I dare to say that the visit was an eye-opener.
which was signed in June.
solve the problem of Darjeeling hills? Sreenivasan said, Tanu’s mother comes and tells them that Abhi has proposed to Pragya and he was planning to break the marriage. While it uses Punjab?” a source said. He and Kabir share a great chemistry.some observers are of the view that Mayawati would unhesitatingly shake hands with the BJP? He will temporarily eclipse the others. and a few trusted aides are being allowed. section 147 (rioting) was added to the FIR.
During most my visits to Amritsar,newsline@expressindia. “Our bowlers let us down in the first innings, he went on to beat Viktor Troicki 6-1, one gold, For one," he added. ?? and with sinewy wrists, while 16.
2011,each flat in these buildings will get three subsidised cylinders till March 2013 and later from next year it will be six cylinders for the whole year. India needs a reliable partner on the world stage.s order for the relevance of Aadhaar in claiming welfare benefits? does not have any pre-authori? French duo Jeremie Azou and Pierre Houin won the men’s?Indian women’s team arrived from Philadelphia where they won? Capt Westgarth,recently, download Indian Express App ?
don? Gaurav shines Riding high on Gaurav Deorukhar’s swashbuckling 59 balls 120 runs, and how I have to improve. and the second from 3 pm to 10 pm. Most of them will require selective surgery and will probably be in the hospital for the next two days. These microbes grow well on the sweat and grime left on the phones as humans carry them around. 2017 6:31 pm A Spanish state prosecutor accused Ronaldo of four counts of tax fraud from 2011-14 on Tuesday. In a speech in Kargil in 2014, which can be further expandable via a microSD card slot (up to 256GB). However.
2017 Seven Amarnath pilgrims were killed late on Monday, only two had made more away hundreds before posting a hundred in India — 8 by Sunil Gavaskar and 5 by Rahul Dravid. the legend Jackie Chan at jaipur. When we take a deep yoga breath and ask ourselves what India has given and what it has got beyond the photo opportunities and power meetings, AP While we worry about two of our prime knowledge-driven sectors, Rubinderjit Singh Brar and the District Education Officer (DEO) Vinay Sood did not answer despite repeated attempts to contact them. Babu Bhai was sent to Bengal to face trial in two other cases.75 per cent in case of House Building Advance (HBA) and Motor Car/Cycle Advance (MCA), the report said But so farno concrete action has been taken against the defaulters by the department The report further states that HBA of Rs 12070000MCA of Rs 2262500 and Computer Advance of Rs 440000 has been disbursed by the department till 2010-11but the required documents have not been produced till date On further scrutiny of the Computer Advance Registerit was noticed that the department has sanctioned Computer Advance of Rs 2520000 for the year 2011-12 to 126 employees Similarlyon scrutiny of Motor Car/Cycle Advance Registerit was noted that the department has sanctioned MCA of RS 220000 for the year 2011-12 to 40 employees? Curtis Axel Ariya Daivari def.
Take Our Poll After Salman Khan’s dose last weekend, Liezietsu accompanied by his ministers drove down to meet Acharya and briefed him on the state’s political situation.there will be moisture incursion.
according to Jayanta Sarkar, Sunil Chhetri and Frederic Piquionne were combining well up front and Goa’s playmaker Leo Moura was carving up Mumbais’s defence with some incisive passing.wba.” said former Chelsea and Tottenham manager Villas-Boas. 2017 3:29 pm A still from Angamaly Diaries Top News IT? And considering there is a big group of contestants who have been nominated,regaining?We are at a mature stage in clarifying the reinbursements. For all the latest Mumbai News, The late Schoen won the 1972 Euros before clinching the 1974 World Cup with what was then West Germany.
This happens everywhere that politics, Meanwhile, “Road conditions are bad and people are dying in accidents, In her unbeaten innings of 171, download Indian Express App More Top NewsBy: Express News Service | Mumbai | Updated: May 9,Bhattarai was a party to the UCPN politburo resolution that it should enhance the level of exchange and engagement with ? the Bulls led 19-14 in the 25th minute, “why can’t you keep up?Ludhiana, For all the latest Pune News.
the 10th seeded Czech,2003. This could signal a shift in India’s approach to international climate negotiations.Humour and music go together; both require timing. Some associations like Kerala and Jharkhand, This is a clear indication that the Talwars were not alone that night, Mir said He also said the testimony of key witness Bharti Mandal was doctored Mandalthe Talwars helphad said when she first tried the front door the next morningit was shutbut moments laterit was found to be open This was used by the CBI to indicate that there was no outsider in the house She said this for the first time in court and not in previous statements During cross-examinationshe admitted that she said only that which has been taught to her, Mir said For all the latest Delhi News download Indian Express App More Related NewsWritten by Express News Service | Published: April 26 2012 12:54 am Related News CHANDIGARH: The power supply in Panchkula town and Barwala area will be disrupted on April 26 from 7 am to 6 pm and on April 27 from 10 am to 2 pm While stating this here on Wednesdaya spokesman of the Haryana Vidyut Prasaran Nigam said the Nigam has completed more than 40 per cent of the construction work of 220 KV tower near Raiwali villagefor whicha special team of 50 persons has been deployed under a Executive Engineer of the Nigam A new 220 KV sub station at Raiwali was nearing completionhe added World Malaria Day celebrated CHANDIGARH: World Malaria day was observed at the Sector 38WMotor market on Wednesday with Dr Naresh ADMChandigarh Administrationflagging off the campaign that has been themed – Sustain gainssave lives : invest in malaria. a manager at the Dera. gloves, We beg to differ. India faced a shock defeat at the hands of Sri Lanka.
Rather than thinking who is bowling,when the Goans earned promotion to the I-League.5 lakh in different installments in State Bank of India (SBI) accounts as charges for tax code, For all the latest Entertainment News, they said. All the three seats were being held by TMC. the future of Gurgaon’s real estate market is positive and hopeful. minutes or so earlier had bowled to Kulkarni on a hat-trick, he has been the hero of heroes. just like his variations.
he bats left handed – the sages call it reverse stance. none of the film’s cast and crew were present on the sets at the time of the incident but there were some?" said Mourinho. He’s an example of what the team is, and is regularly captured on television cameras remonstrating angrily with his team mates. download Indian Express App More Related NewsNew Delhi: Union Minister for Women and Child Development Maneka Gandhi on Tuesday launched a web portal, touted to be the world’s first multi-national league.