This year, String Cheese Incident will return yet again for three magical nights at the legendary Red Rocks Amphitheatre in Colorado. String Cheese Incident is slated to perform for July 21th, 22th, and 23rd, with special guests Jyemo Club, Analog Son, and Grant Farm, respectively. However, in keeping with tradition, Cheese’s keys player Kyle Hollingsworth will throw his annual charity beer festival and concert, Kyle’s Brew Fest, on Thursday, July 20th, to get fans primed and ready for the Red Rocks run that starts the next day.The String Cheese Incident Announces Red Rocks Run, Festival Appearances & MoreKyle’s Brew Fest will serve as the official pre-party for String Cheese’s three-night Red Rocks run, with the proceeds benefitting Conscious Alliance. The festival will go down at Great Divide Brewing Company in Denver’s RiNo district, and is setting itself up to be quite the party. In addition to performances by Kyle Hollingsworth Band, a bunch of special friends are slated to make appearances. Plus, we certainly have no qualms about the 60 craft beers from over 30 breweries that will represented at the event, in addition to the collaboration brews between Kyle and a handful of breweries. For the first time ever, Kyle’s Brew Fest will also feature food pairings, so you can get properly nourished ahead of String Cheese’s Red Rocks run.Certainly, this is not a bad way to kick off your Red Rocks run with String Cheese Incident—especially when considering that it’s for a noble cause. Tickets for the event go on-sale Thursday, May 11th, at 10 a.m. (MST) here, with a limited number of early-bird general-admission and VIP tickets available. VIP tickets include early entry, a tasting and a private brewery tour with Kyle Hollingsworth himself, a signed Red Rocks poster, and a bunch of other goodies.[Cover photo courtesy of Ojeda Photography]
23SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr A credit union’s board of directors is charged with many things, perhaps none more important than hiring and replacing its president and chief executive officer. Should the board look at internal candidates? Should it look outside the credit union’s walls? Or both? Should the board approach the search differently if it wants to turn things around as opposed to staying the course? “There are thousands of credit unions with distinct memberships, boards, and cultures,” says Deedee Myers, CEO of the Phoenix, AZ-based executive recruitment firm DDJ Myers Ltd. (DDM). “Each needs to determine its own best way to proceed.”Here, Deedee and DDJ Myers vice president Peter Myers offer advice for boards sizing up the field and preparing to replace their quarterback.DDM: Turnaround situations could mean several things, including a financial turnaround, a cultural turnaround, or a mixture of both. Financial turnarounds require diverse in-depth leadership competencies that differ from those of growth-oriented CEOs. The competencies of discernment, action, and engagement are primary for turnaround situations.What qualities should a board look for in a CEO when the credit union doesn’t want to merge but does want to go in a new direction? continue reading »
Published on October 24, 2013 at 12:18 am Contact Tyler: [email protected] As No. 3 Syracuse prepared to face No. 1 Maryland last Friday, the key word floating throughout practice was “execute.” Through 69 minutes, the Orange did exactly that and held the Terrapins scoreless while nursing a slim one-goal lead.But it takes only one minute of sloppy play to derail an otherwise masterful performance, and SU found that out the hard way.“They pulled out their goalie, and we just needed to focus on that and how to manage the ball,” sophomore midfielder Emma Russell said. “Unfortunately, we lost that in the last 49 seconds.“At the time, obviously it’s really hard to swallow something like that after controlling the game the whole time.”This weekend, the Orange (12-2, 2-2 Atlantic Coast) will have two opportunities to erase the sour taste from that 2-1 overtime loss, first against No. 16 Wake Forest (10-6, 0-4) on Saturday at 1 p.m. and then against Cornell (8-5, 2-2 Ivy) the following day at 2 p.m.AdvertisementThis is placeholder textThe only way that can happen is if the team follows through on its new one-word mantra.Finish.“The game is 70 minutes, and we played a really good game and executed all but the last minute and a half,” head coach Ange Bradley said. “But we’ve learned that all of us, myself included, could have done different things.”The Orange outplayed the Terrapins throughout the game and nearly was able to pull off the upset.For one, it played excellent defense. Maryland entered the game with 65 goals, including 13 from Jill Witmer. However, Witmer and the other Terrapin skill players failed to find the cage despite generating 16 shots.Additionally, the counterattack was responsible for setting up Karlee Farr’s second-half goal, one that Bradley used “beautiful” twice to describe.But Bradley and the rest of the team know that people will only remember the one lapse in concentration that turned the final outcome on its head.That’s why SU is making sure it doesn’t happen again.“The next time we see this team, we’ll be more rehearsed and more prepared in critical moments of the game, “Bradley said. “Even though it’s a loss in the column, when you can do that and evaluate, that’s a win.”Junior back Jordan Page was admittedly frustrated in the locker room after the game, but she too found a silver lining from the final result. In fact, she and some of the upperclassmen immediately assured everyone there’s no need to panic.“It was a really good learning and growing moment for us, realizing that game management is very important and being able to stop the ball before it gets close to the circle,” Page said. “But the whole game proves and shows all of us that we can compete with the best teams in the country, and we are one of the best teams in the country.”More painful than the loss itself was the hit Syracuse took in the ACC standings. The Orange would have moved into first place with a win, but now sits in third.That’s why Saturday’s contest with the Demon Deacons has added importance. The only way the Orange will be able to fight for the top spot is with a strong finish to the regular season.With three games remaining, that means a full 210 minutes with no mistakes.“It’s something really easily fixed. It’s just important for us mentally to stay there the whole match,” Russell said. “It just keeps replaying in your mind what happened, but all of us just said that it’s better to happen now and we can learn from it for the future.” Comments Facebook Twitter Google+
Harrow Weald’s super-featherweight prospect Mitchell Smith weighed in at 9st 3lb ahead of his English title clash with fellow undefeated fighter Peter Cope.Smith, 21, will face the 23-year-old Hartlepool man at York Hall in Bethnal Green on Wednesday evening for the vacant championship.Cope also weighed in a pound under the 9st 4lb super-featherweight limit.Wembley welterweight Gary Corcoran will be defending his unbeaten record on the same bill. He faces Chris Jenkinson of Bolton.Follow West London Sport on TwitterFind us on Facebook
The cells of every living thing are filled with molecular machines, and one of the most fascinating is a rotary motor called ATP synthase (see April 2002 back issue, opening paragraph). This is a true mechanical/electrical motor, found in every living thing from bacteria to elephants and palm trees. It is really two motors in one; the top part, named F1, is where synthesis of ATP takes place (as described in previous entries on this subject; see Sept. 18 headline, for instance). The bottom machine, named F0, is like a carousel of 10 to 14 proteins labeled c subunits. This is the driving engine of this “splendid molecular machine” that spins at up to 6000 rpm. Somehow, it converts a proton flow into rotation. Ever since the rotary nature of this all-important enzyme was established around 1996, scientists have been eager to explain its operation in detail. According to four Swiss biochemists writing in a Minireview of the December issue of Structure,1 “Energy conversions are central to all life forms,” and this particular motor generates “the universal energy currency of living cells” (ATP). For these reasons, “The central metabolic role of ATP has stimulated much interest in how it is formed using the energy of oxidations or light. Research in this area has led to impressive progress, including some of the most spectacular discoveries in the history of biochemistry” (emphasis added in all quotes). Scientists have made great strides in explaining the F1 part of the machine (see Sept. 18 headline, for instance), but till recently, have been baffled at how the F0 motor generates torque. Now, these scientists present a model that suggests it spins by a water-induced electric potential – a waterwheel, on a 10-nanometer scale.. Their model, illustrated with cartoon drawings in the article, is fascinating, but too involved to describe in detail here. In short, they believe that water channels of different heights in the mitochondrial membrane create an electrical potential difference in the membrane that flows downhill across the stator (labeled with the letter a), a tall housing on the side of the carousel that contains tubes which open and close to prevent proton leakage. The stator looks something like the apparatus in a gumball machine. Think of protons as gumballs, channeled through slots that open up and allow them to roll in or out. Now, add a carousel to your machine that the gumballs have to ride around before dropping into the outlet slot. Then, imagine an electrical charge on the gumballs. As the gumball (proton) drops into its seat, it rides the carousel until it approaches the stator. There, it is repelled by a positively charged entity called Arg227 inside the stator housing, and it falls out. The empty seat, now negatively charged, is attracted by the potential difference between the water-filled inlet and outlet channels in the membrane. The empty seat is thus pushed through the stator, generating torque. Here, a gumball from another channel hops into the empty seat and takes its turn around the carousel. To summarize, water makes the wheel turn, converting electrical energy into mechanical energy, then into chemical energy in the form of ATP. The machinery is reversible. When the electrical potential reverses, the motor runs the other direction, and instead of the machine generating ATP, it consumes ATP and spits out protons. When no potential is present, the motor rocks back and forth in “idling mode” within certain angular limits, allowing protons to migrate into the gumball machine or out of it as the appropriate channels open or close. This can equalize the proton gradient inside and outside the membrane in a controlled manner. The machine would stay in idling mode if it weren’t for the electrical potential. The authors believe that “the membrane potential is the crucial driving force to induce the torque required for ATP synthesis.” Once the F0 carousel gets spinning in high gear, the attached camshaft forces precise conformational changes in the F1 subunits up above, generating three ATP per revolution. “The capacity of this process is impressive,” the authors write; “the daily turnover of a human has been estimated to be 40 kg [about 88 lb] of ATP on average.” Several quadrillions of these motors in your body keep your power plant running (see Feb. 5 headline), making you shine at 116 watts. Other scientists had tried to envision models invoking mechanical energy, thinking that the protein gradient in a c subunit induces a conformational change that turns the wheel. This electrical model, however, seems to not only account for the efficient generation of torque, idling, and reversibility, but also explain why some models of the motor have 14 c subunits (the seats on the carousel) and others have 10 or 11. The number of c subunits is apparently related to the membrane potential. A chloroplast ATP-synthase motor, with 14 subunits, runs at peak efficiency with half the potential (60 mV) required to turn a bacterial motor with 10 or 11 c subunits (120 mV). “To investigate whether this is a general principle and to address the interesting question how the two motors, which operate with a different number of steps, are synchronized, sophisticated biochemical investigations of the enzyme’s performance are required,” they conclude. Speaking of the performance of these machines, scientists have already determined that these motors approach 100% efficiency. Impossible at our scale, these tiny motors “cheat” thermodynamics by using random Brownian motion like a ratchet. Some models of the carousel run on alternate fuel: sodium ions instead of protons (hydrogen ions). A paper in PNAS2 last week discovered something interesting about a similar rotary machine, V0V1-ATP synthase or V-ATPase for short (see Feb. 24 headline). Unlike the F-ATPase model, the two parts of V0V1 can detach and re-attach reversibly. Iwata et al. studied a subunit that apparently clamps onto the two parts like a socket to hold them together, thereby keeping the central shaft locked into its correct position. Maybe this model could be viewed as the travelling carnival carousel that can be dismantled and installed on the road. Apparently V-ATPase motors are needed to maintain acid balance in many parts of the cell. The scientists describe where they are found: “They reside within intracellular compartments, including endosomes, lysosomes, and secretory vesicles, and within plasma membranes of certain cells including renal intercalated cells, osteoclasts, and macrophages. Eukaryotic V-ATPases are responsible for various cell functions including the acidification of intracellular compartments, renal acidification, born [sic; bone?] resorption, and tumor metastasis.”3 V-ATPase has a different-looking camshaft and stator; like F-ATPase, it is found in archaea, bacteria and higher organisms. It does all the ATP synthesis for the kind of bacteria that live in hot springs.1Peter Dimroth, Christoph von Ballmoos, Thomas Meier, and Georg Kaim, “Minireview: Electrical Power Fuels Rotary ATP Synthase,” Structure Vol 11, 1469-1473, December 2003.2Iwata et al., “Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0305165101, published online Dec. 18, 2003.3Presumably, due to a failure in the system; the authors do not elaborate. See this article that suggests increased V-ATPase activity in a tumor is a response aimed at provoking cell death, or apoptosis.A popular book for young people and adults is called The Way Things Work by David Macaulay. He describes the inner workings of car engines, computers, the space shuttle, and many kinds of artificial machines. We need a book like this about cells. Now that we know a cell is composed of thousands of machines, wouldn’t it be cool to see them visualized in a popular way? The definitive textbook The Molecular Biology of the Cell is heavy, expensive ($120) and difficult to read, but creationist reviewers who understand it have remarked that it is filled with powerful evidence for design. We need to get this information before the eyes of the public. ATP synthase just screams for some high-tech, 3D fly-through computer animation. This one molecular machine, so small you would have to shrink yourself down a billionfold to even see it, could demolish Darwinism* all by itself. But then to think that the cell is filled with ten thousands of similar wonders (see yesterday’s headline, for instance, and another article in the same issue of Structure that argues a certain “chaperone machine should be regarded as a molecular motor,” actively employing force to fold a protein), and – well! Does the word overkill mean anything when raised to the fourth power?*Consider that this machine is made up of multiple, discrete units, each one a protein, and each protein is made up of hundreds of amino acids in a precise sequence. The Arg227 described above is an arginine amino acid residue in the 227th position of the stator protein. It is so critical to the operation of the motor, that if that one amino acid is changed to something else, the motor won’t work at all. (Scientists find these things out by artificially mutating individual amino acids and watching what happens.) The motor itself is irreducibly complex, but even more complex is the DNA code that contains all the genetic blueprints for all the parts, and the molecular machinery that builds the parts and then assembles them together in the right order, in the right place, in the right time. Think about how each protein must be folded properly by another host of machines that operate under strict quality control (see Dec. 21 headline). As the coup-de-grace, now realize that every living thing, down to the most primitive bacteria, already have working ATP synthase motors. Can anyone really believe this all evolved by chance? The gulf between the simplest living cell and any precursor is not just a canyon; it’s a light-year. Read our online book, Evolution: Possible or Impossible? if you need a little more convincing.(Visited 21 times, 1 visits today)FacebookTwitterPinterestSave分享0
Related Posts Tags:#Back To School#careers#LinkedIn#networking#now#Students The Dos and Don’ts of Brand Awareness Videos readwrite LinkedIn is looking to capture a younger audience with University Pages, a new feature geared towards helping students explore their college options in ways that go well beyond those available to their parents.More than 200 academic institutions, including NYU, the University of Michigan, UCSD and some notable international universities, have already adopted the new pages. Thousands of additional schools will get access to pages in the coming weeks.The pages provide basic information about the schools, official university updates, and—perhaps most interesting—opportunities for students to identify and even contact other students and alumni. LinkedIn isn’t shy about its ambitions in this area: “Transform those brilliant, creative, hard-working people you met (or will meet) on campus into a lifelong professional network,” its official announcement notes.To pave the way for the college-bound, LinkedIn also lowered its minimum age requirement for users to 14 in the U.S. High school students can join the network as of September 12. Guide to Performing Bulk Email Verification Facebook is Becoming Less Personal and More Pro… A Comprehensive Guide to a Content Audit
By: Bari Sobelson, MS, LMFT Pixabay[Heart Waffle by MoneyforCoffee, May 5, 2016] CCO“What if everything you know about making love is wrong?” Dr. Barbara Fredrickson wants us to know that our typical ways of thinking about love are entirely too limited and do not serve us well. In her Tedx video shared below, Dr. Fredrickson shares some important, and potentially life-changing, information about her findings on love and health. Here are some of the highlights:Taking love off of the romantic pedestal: Perhaps we should start looking at love from a scientific perspective so that we can see that it is so much more than just “that one special person”. Dr. Fredrickson suggests that science doesn’t have to take away the sparkle of love, but can actually teach you how to make love all day long.Making a connection: Love is an emotion. And, like all emotions, love is fleeting. It happens in a span of a micro-moment (hugging a friend, laughing at something funny with a co-worker, smiling at a stranger you see in the car next to you while you are sitting in traffic). When you are truly making a connection with someone else, your heart rhythms, your biochemistries, and your neural firings come into synch.The more connection, the better: We aren’t just talking social and psychological changes for the better here; we are talking physiological changes as well. Dr. Fredrickson has taken a special interest in the vagus nerve which slows your racing heart after you become scared and slows your heart rate a bit each time you exhale. The vagus nerve also establishes your biological capacity for connection. The functioning of the vagus nerve is not stable like we once thought. Dr. Fredrickson has found that if you find ways to increase your daily “diet” of these “micro-moments” (establishing connections) each day, your vagus nerve functioning improves which ultimately results in the rhythms of your heart becoming healthier. These moments of connection are just as good for you as eating a healthy diet and exercising regularly.Every interaction is an opportunity: Fredrickson invites you to open up to the prospect of taking risks and being vulnerable so that you will ultimately be healthier and happier. “Your heart’s capacity for love obeys the biological law of use it or lose it. So, choose love.”Dr. Fredrickson’s research can teach us all something about changing the way we view love and how we can weave this essential element into our daily health regimen.This post was written by Bari Sobelson, MS, LMFT, the Social Media and Programming Coordination Specialist for the MFLN Family Development Team. The MFLN Family Development team aims to support the development of professionals working with military families. Find out more about the Military Families Learning Network Family Development team on our website, Facebook, and Twitter.
Step up your motion design skills with these free After Effects tutorials!Vacations are wrapping up, school is about to begin again, and that sunburn is beginning to flake off. It’s the part of every year that you’ve dreaded since you were five…summer is almost over. However, this summer might end just a little bit sweeter with an awesome series of After Effects tutorials from School of Motion and the Motion Design Department at the Ringling College of Art and Design.The two groups have collaborated to create 30 Days of After Effects which is exactly what the name implies, 30 full-length After Effects tutorials for your viewing pleasure. But these aren’t your run-of-the-mill YouTube tutorials. Each tutorial created by Joey Korenman is 30-60 minutes in length and jam packed with tips and tricks to help you become a better motion graphic designer.Now you may be thinking, ok what’s the catch; are they going to ask me for money? Nope! All 30 After Effects tutorials are completely free.Here’s the first tutorial in the 30 Days of After Effects Series. You can see the rest of the tutorials on School of Motion’s website as they are released.There will be a new School of Motion After Effects tutorial every weekday until September 12th! For more After Effects tricks and tips check out the AE section here on the PremiumBeat blog.
In the week since the first well overflowed in the Olpad village of Surat district, the situation has only worsened for the villagers there. Groundwater has started pouring out at more than 30 spots across this small village, adjacent to the ‘diamond city’. The unusual geological phenomenon, which first came to notice last week, has triggered fear and panic in the region as both ONGC and NICO are engaged in the exploration of gas and petroleum here.The overflow of water, which had started at nearly 15 places across the village last Friday, is still continuing. A source from Olpad confirmed that water was now gushing out from more cracks in the ground and such bursting occurred in at least two cases inside houses of the villagers.Habib Mahammad, a resident, had earlier told Mail Today that the water started overflowing from a well eight feet higher than a nearby pond. “We have no clue as to the reasons for this highly unusual occurrence,” he said. The sweet water in the village’s wells has turned saline and, as a precautionary measure, the district administration has asked the residents not to use it for drinking.Surat collector A. J. Shah said the phenomenon is being investigated by the Gujarat Water Resource Development Corporation (GWRDC) and ONGC. The water tested so far does not contain any hydrocarbons and is safe, he said, adding, ” But we have asked people not to use it anyway.” However, the GWRDC and ONGC are yet to give their reports.advertisementONGC spokesperson L. M. Joshi said the preliminary examination of the overflowed water did not reveal any traces of hydrocarbons in it, which signifies that the queer development had not been caused by the oil or gas explorations.”We have four wells there and NICO has 12, which are mainly gas wells,” Joshi said, adding, “There are no reports of oil or gas coming out of these wells as of now, but we are still checking our wells to ensure that nothing is wrong from our side.” To monitor the situation, joint meetings have taken place among the district authorities, NICO and ONGC officials.However, geologists maintain that the phenomenon could be the result of extensive oil and gas exploration. Prof K. C. Tiwari of the department of geology in Maharaja Sayajirao University (MSU), Baroda, said such incidents could happen due to three reasons.”It could be tidal ingress, an earthquake or the oil and gas explorations,” he said, but hastily discarded the first two theories.”The oil and gas companies often resort to injecting huge volumes of water in the ground to build up pressure for secondary recovery of the resources,” Tiwari said, adding that the bubbles in the water could possibly be due to the presence of gas molecules.Environment activist M. H. Sheikh seconded Prof Tiwari’s last theory. “The exploration in the region is at a very shallow level of 200 to 250 metres. Normally, the exploration is carried out at a depth of 750 metres and beyond,” he said.”The people are scared that the pressure build-up may lead to gas discharge from these wells once the aquifer is exhausted,” Sheikh said.The environmentalist said the development signified “some kind of drastic geological activity” underneath the earth’s surface.”This strange development needs to be studied seriously and adequate measures need to be taken at the earliest. Otherwise, it may lead to a serious fallout soon,” he added.THE WELLS OF WOES- Water started flowing out of wells at 15 places in Olpad last week- Situation has worsened and water is flowing out of 30 spots, including some fissures- Villagers have been advised against drinking the water as it has turned saline- ONGC and NICO denied the role of exploration for this development For more news on India, click here.For more news on Business, click here.For more news on Movies, click here.For more news on Sports, click here.