US, UK, Canada to jointly test plague vaccines

first_img See also: The three countries have been sharing information on plague vaccines since 2000, and the United States and the UK have been working separately to develop them since the 1990s, the DoD said in an Apr 15 news release. The vaccines now being tested are “subunit” vaccines made of particular proteins found on the surface of Y pestis, rather than whole cells. CIDRAP overview of plaguehttp://www.cidrap.umn.edu/cidrap/content/bt/plague/biofacts/index.html Apr 15 DoD news releasehttp://www.defense.gov/releases/release.aspx?releaseid=8397 The vaccine prevented bubonic plague (the most common form of plague, associated with flea bites and leading to swollen lymph nodes, fever, and other symptoms) but did not protect against pneumonic plague (lung infection, usually from inhaling the pathogen). The DoD program is managed by the Joint Vaccine Acquisition Program in the office of the Joint Program Executive Office for Chemical and Biological Defense. Apr 21, 2005 (CIDRAP News) – The US Department of Defense (DoD) has announced plans to collaborate with the defense departments of Canada and the United Kingdom to develop a vaccine for plague, which would fill an empty slot in the nation’s current vaccine arsenal. “This joint effort will continue until late 2005, at which time the DoD will evaluate both vaccine candidates and select one for continued advanced development,” the statement said. A licensed vaccine against plague was available in the United States until 1999, when the single manufacturer stopped making it. It was used to immunize US troops during the Vietnam War, because plague was fairly common in Vietnam at the time. The product was a whole-cell vaccine that used inactivated Yersinia pestis, the plague bacterium. The British vaccine contains the plague organism’s F1 and V antigens, derived separately from recombinant Escherichia coli. “The DoD vaccine contains the F1 and V antigens linked together as a fusion protein,” the DoD statement said. It was developed by the US Army Research Institute of Infectious Diseases and, according to previous reports, has been tested successfully in mice, ferrets, and monkeys. Plague is a fairly uncommon disease in the United States today, with 390 cases reported to the Centers for Disease Control and Prevention from 1947 through 1996. But the plague agent is one of six pathogens the government believes terrorists are most likely to try to use as a biological weapon. An experimental plague vaccine developed by DoD is in a phase 1 clinical trial that began earlier this year at the University of Kentucky, the DoD announcement said. A British plague vaccine candidate will be tested in a separate phase 1 trial in the United States later this year.last_img read more

Hull held by Hammers

first_img Valencia won a back-post header to send Stewart Downing’s cross back across goal and a bundled finish off Sakho’s chest was goalbound until McGregor thrust a glove to his left to make a superb reaction save. Just four minutes later the hosts were ahead. Livermore and Ahmed Elmohamady outmanned Aaron Cresswell on the right wing before the Egyptian swung in a cross. Hernandez was the target and he brushed off the attention of James Tomkins to pick out the bottom corner with a wonderful header. It was a ruthless finish from the 24-year-old, who nearly went one better just before the break. Having been fed by Andy Robertson, he took a single touch on the edge of the box before thudding the crossbar with a piledriver. Jelavic headed home the rebound but came from an offside position. If the Hammers were glad to hear the half-time whistle it barely showed after the restart. They were on the front foot immediately and levelled in the 50th minute courtesy of Valencia’s stunner. He picked the ball up in relatively safe territory, but Dawson’s refusal to close him down allowed the striker to shuffle into range, before crashing home an unstoppable effort. For all the brilliance of the first two goals, the next two were down in large part to defensive error. With 64 minutes gone Cresswell’s loose throw-in was stolen by Diame, who picked Cheikou Kouyate’s pocket, bore down on goal and finished nonchalantly off the inside of the post. This time Hull’s lead lasted less than three minutes and was surrendered in the tamest of fashions. Sakho did well to find space in behind the defence but, having collected Downing’s pass, his low shot was a tame affair. But McGregor failed completely to get a hand on it and the last line of defence, Davies, only succeeded in finishing’s Sakho’s job for him. McGregor was partially redeemed when he pawed Sakho’s header out from under the crossbar, but Hull’s attempts to push for the win – in the shape of two more debutants, Gaston Ramirez and Hatem Ben Arfa – came to nothing. Instead the Hammers almost stole it, Valencia’s header coming off Dawson and hitting the bar. Press Association The home side lost the lead twice, club record signing Hernandez getting the ball rolling with an impeccable first-half header and Diame restoring the advantage against the side he left on transfer deadline day. In between Enner Valencia had marked his first league start with a blockbuster strike from 25 yards and the 2-2 draw was settled when Diafra Sakho’s modest shot evaded Allan McGregor, only for Davies to bundle over his own line. Debut goals from Hull pair Abel Hernandez and Mohamed Diame were only good enough for a draw against West Ham as a Curtis Davies own-goal ensured the spoils were shared in a breathless encounter at the KC Stadium. Valencia almost won it in added time when his header rebounded off Dawson’s shoulder and rattled the crossbar, but that might have been harsh on the home side. Hull can be particularly pleased with the contribution of Hernandez, who also clattered the woodwork in a display that looked a good down payment on the £9.5million sent Palermo’s way, while Diame was desperate to impress against his former employers. West Ham, meanwhile, can rightly be enthused by the forward pairing of Diafra and Valencia, who showed real understanding on their first outing together. It was, in many ways, a shame for the match to be settled by the messiest goal in four, and McGregor in particular will be aggrieved having made two fine saves in the match. The game got off to a lively start, both sides tearing around without taking a breath in the opening minutes. There was more energy than genuine craft in those early exchanges but Diame enjoyed a satisfying moment, taking the ball round his former captain Mark Noble with a deft touch and winning a first ovation from his new fans. Hull came close to making significant breakaways on a couple of occasions, notably when Hernandez’s clever back-heel for Nikica Jelavic almost saw the Croatian in behind the away defence, while Jake Livermore wasted a fine chance to counter with a mis-hit pass. Sakho and Valencia were showing signs of life at the other end of the pitch and the the former must have thought he had opened the scoring in the 35th minute. last_img read more